A Theory of Schizophrenia, Viruses and Pregnancy Due to compensatory changes at dopamine, serotonin, adrenergic and histamine receptor sites in the central nervous system, withdrawal symptoms can occur during abrupt or over-rapid reduction in dosage. The hypothesis Infections during pregnancy activate dormant viruses, disrupting brain development and increasing the risk for schizophrenia later in life. Normally, the viral sequences are harmless and lie dormant—most are relics that cannot be transcribed into proteins.
The Dopamine Hypothesis of Schizophrenia - Mad in America However, despite increasing demand for safe and effective antipsychotic withdrawal protocols or dose-reduction schedules, no specific guidelines with proven safety and efficacy are currently available. The dopamine hypothesis of schizophrenia has been one of the most enduring ideas in psychiatry.” The authors describe how the dopamine hypothesis, which, incidentally, has been around since the late 60’s, has gone through two major revisions.
The "selfish brain" hypothesis for metabolic abnormalities in bipolar. Withdrawal symptoms reported to occur after discontinuation of antipsychotics include nausea; emesis; lightheadedness; diaphoresis; dyskinesia; orthostatic hypotension; tachycardia; insomnia; nervousness; dizziness; headache; non-stop crying; and anxiety. We hypothesize that the metabolic alterations observed in these disorders are a. Keywords Schizophrenia, bipolar disorder, metabolism, brain metabolism.